Altered expression and modulation of activity-regulated cytoskeletal associated protein (Arc) in serotonin transporter knockout rats.

@article{Molteni2009AlteredEA,
  title={Altered expression and modulation of activity-regulated cytoskeletal associated protein (Arc) in serotonin transporter knockout rats.},
  author={Raffaella Molteni and Francesca Calabrese and Paola Francesca Maj and Jocelien D A Olivier and Giorgio Racagni and Bart A Ellenbroek and Marco Andrea Riva},
  journal={European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology},
  year={2009},
  volume={19 12},
  pages={898-904}
}
A gene variant in the human serotonin transporter (SERT) can increase the vulnerability to mood disorders. SERT knockout animals show similarities to the human condition and represent an important tool to investigate the mechanisms underlying the pathologic condition in humans. Along this line of thinking, we used SERT KO rats (SERT(+/-) and SERT(-/-)) to investigate abnormalities in the expression and function of the activity-regulated gene Arc (Activity-regulated cytoskeletal associated… CONTINUE READING

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