Altered expression and distribution of aquaporin-9 in the liver of rat with obstructive extrahepatic cholestasis.

@article{Calamita2008AlteredEA,
  title={Altered expression and distribution of aquaporin-9 in the liver of rat with obstructive extrahepatic cholestasis.},
  author={Giuseppe Calamita and Domenico Ferri and Patrizia Gena and Flavia I. Carreras and Giuseppa Esterina Liquori and Piero Portincasa and Ra{\'u}l Alberto Marinelli and Maria Svelto},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2008},
  volume={295 4},
  pages={
          G682-90
        }
}
Rat hepatocytes express aquaporin-9 (AQP9), a basolateral channel permeable to water, glycerol, and other small neutral solutes. Although liver AQP9 is known for mediating the uptake of sinusoidal blood glycerol, its relevance in bile secretion physiology and pathophysiology remains elusive. Here, we evaluated whether defective expression of AQP9 is associated to secretory dysfunction of rat hepatocytes following bile duct ligation (BDL). By immunoblotting, 1-day BDL resulted in a slight… CONTINUE READING

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