Altered excitation-contraction coupling in myocytes from remodeled myocardium after chronic myocardial infarction.

@article{Kim2002AlteredEC,
  title={Altered excitation-contraction coupling in myocytes from remodeled myocardium after chronic myocardial infarction.},
  author={Y A Kim and S J Kim and Christopher M. Kramer and Atsuko Yatani and Gen Takagi and Sunil V. Mankad and Gyula P{\'e}ter Szigeti and Deepak Ningombam Singh and Sanford P. Bishop and Richard P. Shannon and Dorothy E. Vatner and Stephen F. Vatner},
  journal={Journal of molecular and cellular cardiology},
  year={2002},
  volume={34 1},
  pages={63-73}
}
Following myocardial infarction (MI), the left ventricle undergoes progressive dilatation and eccentric hypertrophy, i.e., remodeling, which is greater in the adjacent than the remote region. The cellular mechanisms underlying these regional differences were studied. One (n=5) and 8 weeks (n=8) after anteroapical MI in sheep, cardiac myocytes were isolated from the adjacent and remote regions. At 8 weeks after MI, myocyte function in the remote region was not different from values either in… CONTINUE READING