Altered enterohepatic circulation of bile acids in Crohn's disease and their clinical significance: a new perspective.

@article{Nolan2013AlteredEC,
  title={Altered enterohepatic circulation of bile acids in Crohn's disease and their clinical significance: a new perspective.},
  author={Jonathan D. Nolan and Ian M. Johnston and J R F Walters},
  journal={Expert review of gastroenterology & hepatology},
  year={2013},
  volume={7 1},
  pages={49-56}
}
The role of bile acids (BA) extends far beyond lipid digestion and cholesterol metabolism. The transcriptional regulation of multiple genes within the liver and intestine are under their influence. BA exert these effects through binding and activating receptors in much the same way as endocrine hormones. The farnesoid X receptor (FXR) is the intracellular… CONTINUE READING