Altered eicosanoid levels in human colon cancer.

  title={Altered eicosanoid levels in human colon cancer.},
  author={Basil Rigas and Ira S. Goldman and Lawrence Levine},
  journal={The Journal of laboratory and clinical medicine},
  volume={122 5},
Eicosanoids may participate in colon carcinogenesis, as evidenced from work in animal tumor models showing prevention of colon cancer by inhibitors of their synthesis and epidemiologic studies demonstrating reduced risk of colon cancer in long-term users of aspirin and other nonsteroidal antiinflammatory drugs (NSAIDs). The levels of prostaglandin E2 (PGE2), PGF2 alpha, PGI2, thromboxane A2 (TXA2), and leukotriene B4 (LTB4), which represent the cyclooxygenase and 5-lipoxygenase pathways, were… CONTINUE READING
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