Altered effector responses of H-Y transgenic CD8+ cells.

  title={Altered effector responses of H-Y transgenic CD8+ cells.},
  author={Ivica Arsov and Stanislav Vukmanovi{\'c}},
  journal={International immunology},
  volume={9 10},
The primary role of CD8+ T cells is to destroy virus-infected or tumor cells expressing cognate antigens in the form of peptide-MHC class I complexes. This destruction is primarily achieved by the actions of lytic mediators and/or lymphokines. In this report, we show that mature, H-Y/Db-specific CD8+ T cells from H-Y TCR transgenic mice were unable to efficiently release lytic mediators after antigenic stimulation. However, anti-TCR antibody induced granule exocytosis and target cell lysis… CONTINUE READING