Altered dynamics of the lysosomal receptor for chaperone-mediated autophagy with age.

@article{Kiffin2007AlteredDO,
  title={Altered dynamics of the lysosomal receptor for chaperone-mediated autophagy with age.},
  author={Roberta Kiffin and Susmita Kaushik and Mei Zeng and Urmi Bandyopadhyay and Cong Zhang and Ashish C. Massey and Marta Mart{\'i}nez-Vicente and Ana Mar{\'i}a Cuervo},
  journal={Journal of cell science},
  year={2007},
  volume={120 Pt 5},
  pages={782-91}
}
Rates of autophagy, the mechanism responsible for lysosomal clearance of cellular components, decrease with age. We have previously described an age-related decline in chaperone-mediated autophagy (CMA), a selective form of autophagy, by which particular cytosolic proteins are delivered to lysosomes after binding to the lysosome-associated membrane protein type 2A (LAMP-2A), a receptor for this pathway. Rates of CMA decrease with age because of a decrease in the levels of LAMP-2A. In this work… CONTINUE READING