Altered drug resistance and recovery from paralysis in Drosophila melanogaster with a deficient histamine-gated chloride channel.

@article{Iovchev2002AlteredDR,
  title={Altered drug resistance and recovery from paralysis in Drosophila melanogaster with a deficient histamine-gated chloride channel.},
  author={Mladen I Iovchev and Plamen Kodrov and Adrian J Wolstenholme and William L. Pak and Eugene P Semenov},
  journal={Journal of neurogenetics},
  year={2002},
  volume={16 4},
  pages={249-61}
}
The recent identification and characterization of two genes, encoding histamine-gated chloride channel subunits from Drosophila melanogaster, has confirmed that histamine is a major neurotransmitter in the fruitfly. One of the cloned genes, hclA (synonyms: HisCl-alpha1; HisCl2), corresponds to ort (ora transientless), mutationsin which affect synaptic transmission in the Drosophila visual system. We identified a mutational change (a null mutation) in the genomic and RNA copies of hclA derived… CONTINUE READING
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