Altered diurnal pattern of salivary substance P in adults with developmental disabilities and chronic self-injury.

@article{Symons2003AlteredDP,
  title={Altered diurnal pattern of salivary substance P in adults with developmental disabilities and chronic self-injury.},
  author={Frank J. Symons and Kelly A Sutton and Cheryl Lyn Walker and James W. Bodfish},
  journal={American journal of mental retardation : AJMR},
  year={2003},
  volume={108 1},
  pages={13-8}
}
Morning and afternoon salivary substance P and cortisol levels were measured in 26 adults with chronic self-injurious behavior (SIB) and severe developmental disabilities and compared with matched controls without SIB. Chronic SIB was associated with an altered diurnal pattern of salivary substance P relative to matched controls, characterized primarily by lower levels of morning substance P, which were significantly correlated with overall severity of SIB. There was a trend for SIB subjects to… CONTINUE READING