Altered distribution of small-conductance calcium-activated potassium channel SK3 in Hirschsprung's disease.

@article{Coyle2015AlteredDO,
  title={Altered distribution of small-conductance calcium-activated potassium channel SK3 in Hirschsprung's disease.},
  author={D. Coyle and A. O'donnell and P. Puri},
  journal={Journal of pediatric surgery},
  year={2015},
  volume={50 10},
  pages={
          1659-64
        }
}
PURPOSE SK3 channels are voltage-independent Ca(2+)-dependent K(+) channels that play a key role in regulating smooth muscle membrane potential during purinergic inhibitory neurotransmission in the colon. Dysmotility problems are common after a properly performed pull-through operation for Hirschsprung's disease (HSCR). We hypothesised that ganglionic bowel just proximal to the transition zone is abnormal and designed this study to investigate SK3 channel expression in HSCR. METHODS Entire… Expand
The impact of down-regulated SK3 expressions on Hirschsprung disease
Aberrant UBR4 expressions in Hirschsprung disease patients

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