Altered distribution of ICa impairs Ca release at the t-tubules of ventricular myocytes from failing hearts

@inproceedings{Bryant2015AlteredDO,
  title={Altered distribution of ICa impairs Ca release at the t-tubules of ventricular myocytes from failing hearts},
  author={Simon M Bryant and Cherrie H. T. Kong and Judy J. Watson and Mark B. Cannell and Andrew F James and Clive H Orchard},
  booktitle={Journal of molecular and cellular cardiology},
  year={2015}
}
In mammalian cardiac ventricular myocytes, Ca influx and release occur predominantly at t-tubules, ensuring synchronous Ca release throughout the cell. Heart failure is associated with disrupted t-tubule structure, but its effect on t-tubule function is less clear. We therefore investigated Ca influx and release at the t-tubules of ventricular myocytes isolated from rat hearts ~18weeks after coronary artery ligation (CAL) or corresponding Sham operation. L-type Ca current (ICa) was recorded… CONTINUE READING
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