Altered dendritic cells (DC) might be responsible for regulatory T cell imbalance and autoimmunity in nonobese diabetic (NOD) mice.

@article{Boudaly2002AlteredDC,
  title={Altered dendritic cells (DC) might be responsible for regulatory T cell imbalance and autoimmunity in nonobese diabetic (NOD) mice.},
  author={Sarah Boudaly and Jo{\"e}lle Morin and Rolande Berthier and Patrice N Marche and Christian Boitard},
  journal={European cytokine network},
  year={2002},
  volume={13 1},
  pages={29-37}
}
Nonobese diabetic (NOD) mice spontaneously develop diabetes, an auto-immune disease characterized by the destruction of insulin-secreting beta-cells by autoreactive T cells. Defects in development and/or functions of dendritic cells (DC) might be critical in eliciting the auto-immune reaction to beta cells in this model. In this paper, DC differentiation in NOD mice was investigated in vitro using bone marrow-derived progenitors (BM-DC) in the presence of GM-CSF and IL-4 or spleen-derived… CONTINUE READING

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