Altered cytokine regulation in the lungs of cigarette smokers.

@article{Mccrea1994AlteredCR,
  title={Altered cytokine regulation in the lungs of cigarette smokers.},
  author={Kimberley A Mccrea and Jeffery E Ensor and K Nall and Eugene Bleecker and Jeffrey D. Hasday},
  journal={American journal of respiratory and critical care medicine},
  year={1994},
  volume={150 3},
  pages={696-703}
}
Cigarette smoking is the major factor responsible for chronic obstructive lung disease, but it occurs in only a minority of smokers. Smoking is associated with increased susceptibility to pulmonary infections and with a neutrophil- and macrophage-rich inflammation of the small airways. We compared concentrations of tumor necrosis factor (TNF), interleukin (IL)-6, and IL-8 in bronchoalveolar lavage fluid (BALF) and measured the capacity of BALF macrophages to release TNF and IL-6 in vitro in… CONTINUE READING
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