Altered cytokine levels in the blood and cerebrospinal fluid of chronic pain patients

  title={Altered cytokine levels in the blood and cerebrospinal fluid of chronic pain patients},
  author={Miroslav “Misha” Backonja and C. L. Coe and Daniel A E Muller and Kathleen Schell},
  journal={Journal of Neuroimmunology},
This study replicates and extends prior reports of abnormal cytokine levels in chronic pain patients and has correlated the alterations with pain severity. In addition, there appeared to be a need to directly assess cerebrospinal fluid (CSF) because previous findings on cytokine concentrations in peripheral circulation have been inconsistent. CSF and blood specimens were obtained from 14 patients with distal painful non-diabetic polyneuropathy (DPPN) or post-traumatic neuralgia (PTN). Elevated… CONTINUE READING


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