• Medicine
  • Published in
    Medical science monitor…
    2007

Altered cyclin D1 genotype distribution in human sporadic pituitary adenomas.

@article{Gaziolu2007AlteredCD,
  title={Altered cyclin D1 genotype distribution in human sporadic pituitary adenomas.},
  author={Nurperi Gazioğlu and Nevin Erensoy and Pinar Kadioglu and Muge Sayitoglu and Ismail Hakki Ersoy and Ozden Hatirnaz and Bunyamin Kısacık and Buge Oz and Mehmet Sar and Uğur Ozbek and Nejat Çiplak and Penbe Çağatay},
  journal={Medical science monitor : international medical journal of experimental and clinical research},
  year={2007},
  volume={13 10},
  pages={
          CR457-63
        }
}
BACKGROUND The cyclin D1 gene (CCND1) is a proto-oncogene playing a critical role in the transition through the G1 to the S phase of the cell cycle and is overexpressed in many tumors. G870A polymorphism at the exon4/intron4 splicing region of the CCND1 gene may play a role in pituitary tumorigenesis and invasiveness. The objective of this study was to examine CCND1 polymorphism in patients with different types of sporadic pituitary adenomas. MATERIAL/METHODS One hundred thirty patients (38… CONTINUE READING

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