Altered connexin expression after peripheral nerve injury.

  title={Altered connexin expression after peripheral nerve injury.},
  author={Karen J. Chandross and John A Kessler and Rick I Cohen and E. Simburger and David Conover Spray and Phyllis L. Bieri and Rolf Dermietzel},
  journal={Molecular and cellular neurosciences},
  volume={7 6},
The identification of connexin32 (Cx32) in myelinating Schwann cells and the association of Cx32 mutations with peripheral neuropathies suggest a functional role for gap junction proteins in the nerve. However, after nerve crush injury, Cx32 expression dramatically decreases in Schwann cells in the degenerating region, returning to control levels at newly formed nodes of Ranvier and Schmidt-Lantermann incisures by 30 days. The present study examined increases in expression of other connexins… CONTINUE READING