Altered cochlear innervation in developing and mature naked and Damaraland mole rats

  title={Altered cochlear innervation in developing and mature naked and Damaraland mole rats},
  author={Catherine M. Barone and Sytse Douma and Dani{\"e}l O J Reijntjes and Brigitte M. Browe and C. K{\"o}ppl and G. Klump and T. Park and S. Pyott},
  journal={The Journal of Comparative Neurology},
  pages={2302 - 2316}
Compared to many other rodent species, naked mole rats (Heterocephalus glaber) have elevated auditory thresholds, poor frequency selectivity, and limited ability to localize sound. Because the cochlea is responsible for encoding and relaying auditory signals to the brain, we used immunofluorescence and quantitative image analysis to examine cochlear innervation in mature and developing naked mole rats compared to mice (Mus musculus), gerbils (Meriones unguiculatus), and Damaraland mole rats… Expand
5 Citations
Functional, Morphological, and Evolutionary Characterization of Hearing in Subterranean, Eusocial African Mole-Rats
The findings suggest that altered hearing in African mole-rats is adaptive, perhaps tailoring hearing to eusocial and subterranean lifestyles, and establishes species members as naturally occurring disease models to investigate human hearing loss. Expand
Preparation of the intact rodent organ of Corti for RNAscope and immunolabeling, confocal microscopy, and quantitative analysis
Summary This protocol describes the preparation of the mouse organ of Corti for RNAscope, immunolabeling, confocal microscopy, and quantitative image analysis to examine transcript and proteinExpand
XIAP inhibits gentamicin-induced hair cell damage and ototoxicity through the caspase-3/9 pathway.
It is suggested that XIAP reduces GM-induced ototoxicity and caspase-3/9 pathway is associated with this process. Expand
Volume gradients in inner hair cell-auditory nerve fiber pre- and postsynaptic proteins differ across mouse strains
Analysis of organs of Corti isolated from CBA/CaJ, C57BL/6, and FVB/NJ mice using immunofluorescence, confocal microscopy, and quantitative image analysis finds consistent expression of presynaptic volume gradients across strains of mice and inconsistent expression of postsynapticVolume gradients. Expand
Altered cochlear innervation in developing and mature naked and Damaraland mole rats
Differences in cochlear innervation specifically between the two subterranean rodents and more broadly among rodents provides insight into the coChlear mechanisms that enhance frequency sensitivity and sound localization, maturation of the auditory system, and the evolutionary adaptations occurring in response to subterranean environments. Expand


Structural Changes and Lack of HCN1 Channels in the Binaural Auditory Brainstem of the Naked Mole-Rat (Heterocephalus glaber)
Naked mole-rats possess a well structured medial superior olive, with a similar synaptic arrangement to interaural-time-difference encoding animals, and binaural auditory brainstem nuclei lack the membrane-bound hyperpolarization-activated channel HCN1, a voltage-gated ion channel that greatly contributes to the fast integration times in bINAural nuclei of the superior olivary complex in other species. Expand
The sensory epithelium and its innervation in the mole rat cochlea
The goal of this study was to elucidate the structural basis for adaptation of the auditory end‐organ to an environment where low‐frequency acoustical signals prevail and find the innervation of outer hair cells was most uncommon. Expand
Ear Structures of the Naked Mole-Rat, Heterocephalus glaber, and Its Relatives (Rodentia: Bathyergidae)
Substantial intraspecific differences were found in certain middle and inner ear structures, which might reflect a lack of selective pressure on its peripheral auditory system and also result from relaxed selective pressures. Expand
Perineuronal nets in subcortical auditory nuclei of four rodent species with differing hearing ranges
It is found that some auditory nuclei exhibit dramatic differences in PN distribution among species while other nuclei have consistent PN distributions, and that PNs exhibit molecular heterogeneity, and can stain with either marker individually or with both. Expand
Features of visual function in the naked mole-rat Heterocephalus glaber
The eyes and visual capacity of the naked mole-rat, Heterocephalus glaber, a subterranean rodent, were evaluated using anatomical, biochemical, and functional assays, and compared to other rodents ofExpand
Selective removal of lateral olivocochlear efferents increases vulnerability to acute acoustic injury.
It is suggested that the LOC modulates cochlear nerve excitability and protects the cochlea from neural damage in acute acoustic injury. Expand
Degenerate hearing and sound localization in naked mole rats (Heterocephalus glaber), with an overview of central auditory structures
The fact that subterranean mammals have little use for vision in a lightless environment suggests that naked mole rats represent an extreme case in this relationship and may explain the fact that, unlike surface‐dwelling mammals, they have virtually lost the ability to localize brief sounds. Expand
A physiological place–frequency map of the cochlea in the CBA/J mouse
The simple logarithmic place-frequency relation found in the mouse indicates that mice are acoustic generalists rather than specialists. Expand
The cochlear place-frequency map of the adult and developing mongolian gerbil
The place-frequency map of the gerbil was determined by iontophoretic application of horseradish peroxidase in physiologically characterized single auditory nerve fibers from a '3-dimensional' reconstruction of the cochleae. Expand
Development of the inner ear efferent system across vertebrate species.
  • D. Simmons
  • Biology, Medicine
  • Journal of neurobiology
  • 2002
Recent data on the neurogenesis, pathfinding, target selection, innervation, and onset of neurotransmitter expression in cholinergic efferent neurons are summarized. Expand