Altered cholesterol synthesis as a mechanism involved in methyl isobutyl ketone-potentiated experimental cholestasis.

@article{Duguay1997AlteredCS,
  title={Altered cholesterol synthesis as a mechanism involved in methyl isobutyl ketone-potentiated experimental cholestasis.},
  author={A B Duguay and Gabriel L. Plaa},
  journal={Toxicology and applied pharmacology},
  year={1997},
  volume={147 2},
  pages={281-8}
}
Mechanisms by which ketones potentiate manganese-bilirubin (Mn-BR)-induced cholestasis are unknown. The purpose of the present study was to investigate the effect of methyl isobutyl ketone (MiBK), a widely used ketonic solvent, at the level of the bile canalicular membrane (BCM) and to verify if altered membrane lipid dynamics could be involved in MiBK… CONTINUE READING