Altered cerebellar development in mice lacking pituitary adenylate cyclase-activating polypeptide.

@article{Allais2007AlteredCD,
  title={Altered cerebellar development in mice lacking pituitary adenylate cyclase-activating polypeptide.},
  author={Aur{\'e}lie Allais and Delphine C Burel and Emma Rachel Isaac and Sarah L. Gray and Magali Basille and Aur{\'e}lia Ravni and Nancy McKeown Sherwood and Hubert Vaudry and Bruno J. Gonzalez},
  journal={The European journal of neuroscience},
  year={2007},
  volume={25 9},
  pages={2604-18}
}
Previous studies have demonstrated that pituitary adenylate cyclase-activating polypeptide (PACAP) exerts trophic effects during neurodevelopment. In particular, the occurrence of PACAP and its receptors in the cerebellum during pre- and postnatal periods suggests that it could play a crucial role in ontogenesis of this structure. To test this hypothesis, we compared the histogenesis of cerebellar cortex in wild-type and PACAP-knockout (PACAP-/-) mice at postnatal days (P)4 and 7. Morphometric… CONTINUE READING