Altered cell fate in LiCl-treated sea urchin embryos.

  title={Altered cell fate in LiCl-treated sea urchin embryos.},
  author={C Nocente-McGrath and R M McIsaac and Susan G. Ernst},
  journal={Developmental biology},
  volume={147 2},
Endo16 is a lineage-specific protein expressed during embryogenesis in the sea urchin, Strongylocentrotus purpuratus. We have examined the effects of various concentrations of lithium chloride, a well-known vegetalizing agent, on Endo16 expression in whole sea urchin embryos. Our results show that treatment with LiCl causes increased steady-state levels of Endo16 transcripts. An increase in the number of endodermal cells in treated embryos demonstrates a change in cell lineage. In addition, we… CONTINUE READING

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Lithium evokes expression of vegetal-specific molecules in the animal blastomeres of sea urchin embryos.

Proceedings of the National Academy of Sciences of the United States of America • 1989
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