Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53.

Abstract

Gene amplification occurs at high frequency in transformed cells (10(-3)-10(-5)), but is undetectable in normal diploid fibroblasts (less than 10(-9)). This study examines whether alterations of one or both p53 alleles were sufficient to allow gene amplification to occur. Cells retaining one wild-type p53 allele mimicked the behavior of primary diploid… (More)

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Cite this paper

@article{Livingstone1992AlteredCC, title={Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53.}, author={Laura R Livingstone and Arthur White and Jeffrey S Sprouse and Elizabeth M. Livanos and Tyler E. Jacks and Thea D. Tlsty}, journal={Cell}, year={1992}, volume={70 6}, pages={923-35} }