Altered cardiovascular haemodynamics and baroreceptor-heart rate reflex in adult sheep after prenatal exposure to dexamethasone.

@article{Dodic1999AlteredCH,
  title={Altered cardiovascular haemodynamics and baroreceptor-heart rate reflex in adult sheep after prenatal exposure to dexamethasone.},
  author={Miodrag Dodic and Arianne Peers and John P. Coghlan and Clive N. May and Eugenie R Lumbers and Z Y Yu and E. Marelyn Wintour},
  journal={Clinical science},
  year={1999},
  volume={97 1},
  pages={103-9}
}
Numerous epidemiological studies, together with mounting evidence from studies in animals, point to a correlation between an adverse intrauterine environment and the early onset of cardiovascular and metabolic diseases later in life. We were the first to show that sheep exposed to dexamethasone (0.28 mg.kg-1.day-1 for only 2 days) at the end of the first month of pregnancy (PTG1), but not those exposed at the end of the second month of pregnancy (PTG2), had a higher basal mean arterial pressure… CONTINUE READING