Altered cardiac sarcoplasmic reticulum function of intact myocytes of rat ventricle during metabolic inhibition.

@article{Overend2001AlteredCS,
  title={Altered cardiac sarcoplasmic reticulum function of intact myocytes of rat ventricle during metabolic inhibition.},
  author={C L Overend and David J. Eisner and S C O'neill},
  journal={Circulation research},
  year={2001},
  volume={88 2},
  pages={181-7}
}
Changes in the behavior of the sarcoplasmic reticulum (SR) in rat ventricular myocytes were investigated under conditions of metabolic inhibition using laser-scanning confocal microscopy to measure intracellular Ca(2+) and the perforated patch-clamp technique to measure SR Ca(2+) content. Metabolic inhibition had several effects on SR function, including reduced frequency of spontaneous releases of Ca(2+) (sparks and waves of Ca(2+)-induced Ca(2+) release), increased SR Ca(2+) content (79.4+/-5… CONTINUE READING
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