Altered calcium-mediated cell signaling in keratinocytes cultured from patients with neurofibromatosis type 1.

@article{Korkiamki2002AlteredCC,
  title={Altered calcium-mediated cell signaling in keratinocytes cultured from patients with neurofibromatosis type 1.},
  author={Timo Korkiam{\"a}ki and Heli Yl{\"a}-Outinen and Jussi Koivunen and S. M. Karvonen and Juha M. Peltonen},
  journal={The American journal of pathology},
  year={2002},
  volume={160 6},
  pages={1981-90}
}
Capacitative calcium entry and calcium wave propagation were studied in keratinocytes cultured from control persons and patients with type 1 neurofibromatosis. The cells were stimulated mechanically in the presence of inhibitors of gap-junctional or ATP-mediated communication to determine which pathways are operative in Ca(2+) signaling between these cells. Keratinocytes cultured from patients with type 1 neurofibromatosis (NF1) had a tendency to form cultures with markedly altered calcium… CONTINUE READING

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