Altered calcium homeostasis in irreversibly injured P388D1 macrophages.

  title={Altered calcium homeostasis in irreversibly injured P388D1 macrophages.},
  author={G F Gleva and Lee A. Goodglick and Agnes B. Kane},
  journal={The American journal of pathology},
  volume={137 1},
Sequestration of calcium by mitochondria is an important mechanism to maintain normal intracellular calcium homeostasis. Anoxic or toxic damage to these organelles has been postulated to disrupt intracellular calcium compartmentalization, leading to cell death. The authors examined the potential relationship between mitochondrial dysfunction, altered calcium homeostasis, and irreversible injury in a model system of silica-induced toxicity to P388D1 cells. Exposure to toxic silica particles, but… CONTINUE READING