Altered cAMP-dependent protein kinase A in platelets of patients with obsessive-compulsive disorder.

@article{Prez2000AlteredCP,
  title={Altered cAMP-dependent protein kinase A in platelets of patients with obsessive-compulsive disorder.},
  author={J. Zu{\~n}iga P{\'e}rez and Daniela Tardito and Luigi Ravizza and Giorgio Racagni and Silvia Mori and G. Maina},
  journal={The American journal of psychiatry},
  year={2000},
  volume={157 2},
  pages={284-6}
}
OBJECTIVE The purpose of this study was to assess cAMP-dependent protein kinase A in patients with obsessive-compulsive disorder (OCD). METHOD The levels and the activity of protein kinase A were evaluated in whole platelets obtained from 12 unmedicated patients with OCD and 15 healthy comparison subjects. RESULTS The immunolabeling of protein kinase A regulatory subunits type I and II were significantly greater but that of the catalytic subunit significantly lower in patients with OCD than… CONTINUE READING