Altered cAMP and Ca2+ signaling in mouse pancreatic islets with glucagon-like peptide-1 receptor null phenotype.

@article{Flamez1999AlteredCA,
  title={Altered cAMP and Ca2+ signaling in mouse pancreatic islets with glucagon-like peptide-1 receptor null phenotype.},
  author={Daisy Flamez and Patrick Gilon and Karen Moens and A Van Breusegem and Dominique Delmeire and Louise A. Scrocchi and Jean-Claude Henquin and Daniel J Drucker and Frans Schuit},
  journal={Diabetes},
  year={1999},
  volume={48 10},
  pages={
          1979-86
        }
}
1-Cells from rodents and humans express different receptors recognizing hormones of the secretin-glucagon family, which--when activated--synergize with glucose in the control of insulin release. We have recently reported that isolated islets from mice homozygous for a GLP-1 receptor null mutation (GLP-1R(-/-)) exhibit a well-preserved insulin-secretory response to glucose. This observation can be interpreted in two different ways: 1) the presence of GLP-1R is not essential for the secretory… CONTINUE READING
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