Altered brain white matter integrity in healthy carriers of the APOE epsilon4 allele: a risk for AD?

@article{Persson2006AlteredBW,
  title={Altered brain white matter integrity in healthy carriers of the APOE epsilon4 allele: a risk for AD?},
  author={Jonas Persson and Johanna Lind and Anne Larsson and Martin Ingvar and Marc Cruts and Christine van Broeckhoven and Rolf Adolfsson and L. -G. Nilsson and Lars Nyberg},
  journal={Neurology},
  year={2006},
  volume={66 7},
  pages={1029-33}
}
BACKGROUND Previous research has shown that polymorphisms of apolipoprotein E (APOE) represent genetic risk factors for dementia and for cognitive impairment in the elderly. The neural mechanisms by which these genetic variations influence behavioral performance or clinical severity are not well understood. METHODS The authors used diffusion tensor imaging to investigate ultrastructural properties in brain white matter to detect pathologic processes that modify tissue integrity. Sixty… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 49 extracted citations

Similar Papers

Loading similar papers…