Altered brain response to verbal learning following sleep deprivation

@article{Drummond2000AlteredBR,
  title={Altered brain response to verbal learning following sleep deprivation},
  author={Sean P. A. Drummond and Gregory G. Brown and J. Christian Gillin and John L. Stricker and Eric C. Wong and Richard B. Buxton},
  journal={Nature},
  year={2000},
  volume={403},
  pages={655-657}
}
The effects of sleep deprivation on the neural substrates of cognition are poorly understood. Here we used functional magnetic resonance imaging to measure the effects of 35 hours of sleep deprivation on cerebral activation during verbal learning in normal young volunteers. On the basis of a previous hypothesis, we predicted that the prefrontal cortex (PFC) would be less responsive to cognitive demands following sleep deprivation. Contrary to our expectations, however, the PFC was more… 
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