Altered brain lipid composition in cyclooxygenase-2 knockout mouse.

@article{Ma2007AlteredBL,
  title={Altered brain lipid composition in cyclooxygenase-2 knockout mouse.},
  author={Kaizong Ma and Robert Langenbach and Stanley I. Rapoport and Mireille Basselin},
  journal={Journal of lipid research},
  year={2007},
  volume={48 4},
  pages={
          848-54
        }
}
  • Kaizong Ma, Robert Langenbach, +1 author Mireille Basselin
  • Published in Journal of lipid research 2007
  • Biology, Medicine
  • Cyclooxygenase (COX)-2 plays an important role in brain arachidonic acid (20:4n-6) metabolism, and its expression is upregulated in animal models of neuroinflammation and excitotoxicity. Our hypothesis was that brain lipid composition would be altered in COX-2 knockout (COX-2(-/-)) compared with wild-type (COX-2(+/+)) mice, reflecting the important role of COX-2 in brain lipid metabolism. Concentrations of different lipids were measured in high-energy microwaved brain from COX-2(-/-) and COX-2… CONTINUE READING

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