Altered brain and gut responses to corticotropin-releasing hormone (CRH) in patients with irritable bowel syndrome

@inproceedings{Kano2017AlteredBA,
  title={Altered brain and gut responses to corticotropin-releasing hormone (CRH) in patients with irritable bowel syndrome},
  author={M. Kano and Tomohiko Muratsubaki and Lukas Van Oudenhove and Joe Morishita and Makoto Yoshizawa and Keiji Kohno and Mao Yagihashi and Yukari Tanaka and Shunji Mugikura and Patrick Dupont and Huynh Giao Ly and K Takase and Motoyori Kanazawa and Shin Fukudo},
  booktitle={Scientific Reports},
  year={2017}
}
Stress is a known trigger of irritable bowel syndrome (IBS) and exacerbates its gastrointestinal symptoms. However, underlying the physiological mechanism remains unknown. Here, we investigated hypothalamic–pituitary–adrenal (HPA) axis, colonic motility, and autonomic responses to corticotropin-releasing hormone (CRH) administration as well as brain activity alterations in IBS. The study included 28 IBS patients and 34 age and sex-matched healthy control subjects. IBS patients demonstrated… CONTINUE READING
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