Altered brain activation in cognitively intact individuals at high risk for Alzheimer's disease.

@article{Smith1999AlteredBA,
  title={Altered brain activation in cognitively intact individuals at high risk for Alzheimer's disease.},
  author={Charles D. Smith and Anders H. Andersen and Richard J. Kryscio and Frederick A. Schmitt and Mark S Kindy and Lee Xenakis Blonder and Malcolm Avison},
  journal={Neurology},
  year={1999},
  volume={53 7},
  pages={1391-6}
}
OBJECTIVE To determine whether brain function is altered in cognitively normal individuals at high risk for AD several years before the typical age at onset for this illness. BACKGROUND Neuropathologic alterations in AD precede cognitive impairment by several years. It is unknown whether functional alterations in neural circuitry accompany these neuropathologic changes, and if so, whether they may be detectable before onset of symptoms. METHODS We used functional MRI to compare cortical… CONTINUE READING

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