Altered binding of human histone gene transcription factors during the shutdown of proliferation and onset of differentiation in HL-60 cells.

@article{Stein1989AlteredBO,
  title={Altered binding of human histone gene transcription factors during the shutdown of proliferation and onset of differentiation in HL-60 cells.},
  author={Gary S Stein and Jane B Lian and Janet L Stein and R. B. Briggs and Victoria Shalhoub and Kenneth L. Wright and Urs Pauli and Andre J van Wijnen},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1989},
  volume={86 6},
  pages={1865-9}
}
Two sites of protein-DNA interaction have been identified in vivo and in vitro in the proximal promoter regions of an H4 and an H3 human histone gene. In proliferating cells, these genes are transcribed throughout the cell cycle, and both the more distal site I and the proximal site II are occupied by promoter-binding factors. In this report we demonstrate that during the shutdown of proliferation and onset of differentiation of the human promyelocytic leukemia cell line HL-60 into cells that… CONTINUE READING