Altered behavioural response to acute stress in mice lacking cellular prion protein

  title={Altered behavioural response to acute stress in mice lacking cellular prion protein},
  author={Patr{\'i}cia Barreto Costa Nico and Fernanda de-Paris and E. Vinad{\'e} and O. Amaral and M. Bianchin},
  journal={Behavioural Brain Research},
  • Patrícia Barreto Costa Nico, Fernanda de-Paris, +2 authors M. Bianchin
  • Published 2005
  • Psychology, Medicine
  • Behavioural Brain Research
  • Although many studies have investigated the function of cellular prion protein (PrPc), its physiologic role remains elusive. PrPc null mice have been reported to develop normally and to show normal performance in most behavioural tests. In the present study we investigated whether this also holds true after episodes of acute stress. PrPc gene ablated (Prnp0/0) and wild-type mice were subjected to restraint stress, electric foot shock, or swimming and compared with non-stressed animals… CONTINUE READING
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