Altered axonal targeting and short-term plasticity in the hippocampus of Disc1 mutant mice.

  title={Altered axonal targeting and short-term plasticity in the hippocampus of Disc1 mutant mice.},
  author={Mirna Kvajo and Heather Marie McKellar and Liam John Drew and Aude-Marie Lepagnol-Bestel and Lan Xiao and Rebecca J Levy and Richard Blazeski and P Alexander Arguello and Clay O. Lacefield and Carol Ann Mason and Michel Simonneau and James M. O'Donnell and Amy B Macdermott and Maria Karayiorgou and Joseph A Gogos},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={108 49},
Carefully designed animal models of genetic risk factors are likely to aid our understanding of the pathogenesis of schizophrenia. Here, we study a mouse strain with a truncating lesion in the endogenous Disc1 ortholog designed to model the effects of a schizophrenia-predisposing mutation and offer a detailed account of the consequences that this mutation has on the development and function of a hippocampal circuit. We uncover widespread and cumulative cytoarchitectural alterations in the… CONTINUE READING
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A mutation in mouse Disc1 that models a schizophrenia risk allele leads to specific alterations in neuronal architecture and cognition

  • M Kvajo
  • Proc Natl Acad Sci USA
  • 2008
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