Altered asymmetric dimethyl arginine metabolism in allergically inflamed mouse lungs.

@article{Ahmad2010AlteredAD,
  title={Altered asymmetric dimethyl arginine metabolism in allergically inflamed mouse lungs.},
  author={Tanveer Ahmad and Ulaganathan Mabalirajan and Balaram Ghosh and Anurag Agrawal},
  journal={American journal of respiratory cell and molecular biology},
  year={2010},
  volume={42 1},
  pages={3-8}
}
Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase (NOS), causes uncoupling of NOS leading to generation of reactive nitrogen species, such as peroxynitrite. The lung generates a significant amount of ADMA, potentially contributing to plasma ADMA levels that have been related to endothelial dysfunction. ADMA infusion causes increased collagen deposition in lungs, suggesting that it could influence the development of chronic lung diseases such as fibrosis… CONTINUE READING
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