Altered architecture of substrate binding region defines the unique specificity of UDP-GalNAc 4-epimerases.

Abstract

UDP-hexose 4-epimerases play a pivotal role in lipopolysaccharide (LPS) biosynthesis and Leloir pathway. These epimerases are classified into three groups based on whether they recognize nonacetylated UDP-hexoses (Group 1), both N-acetylated and nonacetylated UDP-hexoses (Group 2) or only N-acetylated UDP-hexoses (Group 3). Although the catalysis has been… (More)
DOI: 10.1002/pro.611

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