Altered aortic prostaglandin synthesis in a mild form of diabetes and the influence of dietary cholesterol.

@article{Wey1984AlteredAP,
  title={Altered aortic prostaglandin synthesis in a mild form of diabetes and the influence of dietary cholesterol.},
  author={Huan-Yun Wey and M. T. Ravi Subbiah},
  journal={The Journal of laboratory and clinical medicine},
  year={1984},
  volume={104 3},
  pages={312-20}
}
Extreme hyperglycemia (350 mg/dl) in rats results from streptozocin injection (50 mg/kg) and leads to a reduced aortic capacity for prostacyclin synthesis. Other complications such as hyperlipemia and alterations in body weight gain (loss or no gain) that might be responsible for the altered aortic prostacyclin synthesis occur concurrently. We injected neonatal rats (2 days of age) with intraperitoneal streptozocin to induce chronic mild diabetes (mean plasma glucose, 241 mg/dl) characterized… CONTINUE READING