Altered antioxidant defence in a mouse adriamycin model of glomerulosclerosis.

@article{Deman2001AlteredAD,
  title={Altered antioxidant defence in a mouse adriamycin model of glomerulosclerosis.},
  author={An Deman and Bart Ceyssens and M. R. T. Pauwels and Jun-Jun Zhang and Katherina Vanden Houte and Dierik L Verbeelen and Christiane van den Branden},
  journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association},
  year={2001},
  volume={16 1},
  pages={
          147-50
        }
}
BACKGROUND Antioxidant enzyme status changes in experimental models of chronic renal disease with glomerulosclerosis. Most of the studies are performed in rats. We now investigate whether a mouse model with more rapid development of glomerulosclerosis is suitable for the study of radical-associated renal disease. METHODS Female BALB/c mice are injected intravenously with a single dose of adriamycin (10 mg/kg). The development of glomerular and interstitial injury is evaluated by means of… CONTINUE READING
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