Altered antigenicities of hepatitis B virus surface antigen carrying mutations outside the common “a” determinant

  title={Altered antigenicities of hepatitis B virus surface antigen carrying mutations outside the common “a” determinant},
  author={Wei Ning Chen and Chong Jin Oon and Ivy Toh},
  journal={American Journal of Gastroenterology},
TO THE EDITOR: The antigenic region of hepatitis B virus (HBV) is located on the viral surface antigen (HBsAg) (1). Initially contained within a well conserved “a” determinant (amino acid residue 124–147), recently reported mutations that have emerged after vaccination or antiviral drug therapy are distributed on the expanded region of the HBsAg, namely, the major hydrophilic region (MHR, amino acid residues 100–160) (2–4). Altered antigenicities have been shown for those mutations occurring on… CONTINUE READING


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