Altered amygdala and hippocampus function in adolescents with hypercortisolemia: a functional magnetic resonance imaging study of Cushing syndrome.

@article{Maheu2008AlteredAA,
  title={Altered amygdala and hippocampus function in adolescents with hypercortisolemia: a functional magnetic resonance imaging study of Cushing syndrome.},
  author={Francoise S. Maheu and L. C. A. Mazzone and Deborah P. Merke and Margaret F. Keil and Constantine A Stratakis and Daniel S. Pine and Monique Ernst},
  journal={Development and psychopathology},
  year={2008},
  volume={20 4},
  pages={1177-89}
}
Chronic elevations of endogenous cortisol levels have been shown to alter medial temporal cortical structures and to be accompanied by declarative memory impairments and depressive symptoms in human adults. These effects of elevated endogenous levels of cortisol have not been directly studied in adolescents. Because adolescents with Cushing syndrome show endogenous elevations in cortisol, they represent a unique natural model to study the effects of prolonged hypercortisolemia on brain function… CONTINUE READING

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