Altered age-related trajectories of amygdala-prefrontal circuitry in adolescents at clinical high risk for psychosis: a preliminary study.

@article{Gee2012AlteredAT,
  title={Altered age-related trajectories of amygdala-prefrontal circuitry in adolescents at clinical high risk for psychosis: a preliminary study.},
  author={Dylan G. Gee and Katherine H. Karlsgodt and Theo G M van Erp and Carrie E. Bearden and Matthew D. Lieberman and Aysenil Belger and Diana O. Perkins and Doreen M. Olvet and Barbara A. Cornblatt and Todd Constable and Scott W. Woods and Jean Addington and Kristin S. Cadenhead and Thomas H. McGlashan and Larry J. Seidman and Ming T. Tsuang and Elaine F. Walker and Tyrone D. Cannon},
  journal={Schizophrenia research},
  year={2012},
  volume={134 1},
  pages={1-9}
}
Emotion processing deficits are prominent in schizophrenia and exist prior to the onset of overt psychosis. However, developmental trajectories of neural circuitry subserving emotion regulation and the role that they may play in illness onset have not yet been examined in patients at risk for psychosis. The present study employed a cross-sectional analysis to examine age-related functional activation in amygdala and prefrontal cortex, as well as functional connectivity between these regions, in… CONTINUE READING
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