Altered activities of transcription factors and their related gene expression in cardiac tissues of diabetic rats.

@article{Nishio1998AlteredAO,
  title={Altered activities of transcription factors and their related gene expression in cardiac tissues of diabetic rats.},
  author={Yoshihiko Nishio and Atsunori Kashiwagi and Hirofumi Taki and Kazuya Shinozaki and Yasuhiro Maeno and Hideyuki Kojima and Hiroshi Maegawa and Masakazu Haneda and Hiroyoshi Hidaka and Hitoshi Yasuda and Kihachiro Horiike and Ryuichi Kikkawa},
  journal={Diabetes},
  year={1998},
  volume={47 8},
  pages={1318-25}
}
Gene regulation in the cardiovascular tissues of diabetic subjects has been reported to be altered. To examine abnormal activities in transcription factors as a possible cause of this altered gene regulation, we studied the activity of two redox-sensitive transcription factors--nuclear factor-kappaB (NF-kappaB) and activating protein-1 (AP-1)--and the change in the mRNA content of heme oxygenase-1, which is regulated by these transcription factors in the cardiac tissues of rats with… CONTINUE READING

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