Altered T cell ligands derived from a major house dust mite allergen enhance IFN-gamma but not IL-4 production by human CD4+ T cells.

@article{Tsitoura1996AlteredTC,
  title={Altered T cell ligands derived from a major house dust mite allergen enhance IFN-gamma but not IL-4 production by human CD4+ T cells.},
  author={Daphne C. Tsitoura and Adrienne Verhoef and Colin M. Gelder and Robyn E O'Hehir and Jonathan Robert Lamb},
  journal={Journal of immunology},
  year={1996},
  volume={157 5},
  pages={2160-5}
}
Changes in the affinity of the interaction between T cell Ag receptors and their ligands can modulate selected T cell effector functions. Since both allergen-specific Th2 and Th0 cells are present in the peripheral CD4+ T cell pool of atopic individuals, the potential to inhibit cytokine production by Th2 cells and promote Th1-type cytokines from Th0 cells may contribute to the down-regulation of allergic inflammation. The aim of this study was to investigate the effects of peptide analogues of… CONTINUE READING
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