Altered Smooth Muscle Cell Force Generation as a Driver of Thoracic Aortic Aneurysms and Dissections.

@article{Milewicz2017AlteredSM,
  title={Altered Smooth Muscle Cell Force Generation as a Driver of Thoracic Aortic Aneurysms and Dissections.},
  author={Dianna Milewicz and Kathleen M Trybus and Dong-chuan Guo and H Lee Sweeney and Ellen S. Regalado and Kristine E. Kamm and James T Stull},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2017},
  volume={37 1},
  pages={26-34}
}
The importance of maintaining contractile function in aortic smooth muscle cells (SMCs) is evident by the fact that heterozygous mutations in the major structural proteins or kinases controlling contraction lead to the formation of aneurysms of the ascending thoracic aorta that predispose to life-threatening aortic dissections. Force generation by SMC… CONTINUE READING