Altered S-nitrosylation of p53 is responsible for impaired antioxidant response in skeletal muscle during aging

Abstract

p53 transcriptional activity has been proposed to regulate both homeostasis and sarcopenia of skeletal muscle during aging. However, the exact molecular function of p53 remains to be clearly defined. We demonstrated a requirement of nuclear p53 S-nitrosylation in inducing a nitric oxide/PGC-1α-mediated antioxidant pathway in skeletal muscle. Importantly… (More)
DOI: 10.18632/aging.101139

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