Altered Purkinje cell miRNA expression and SCA1 pathogenesis

  title={Altered Purkinje cell miRNA expression and SCA1 pathogenesis},
  author={Edgardo Rodr{\'i}guez-Lebr{\'o}n and Gumei Liu and Megan Kathryn Keiser and Mark A Behlke and Beverly L. Davidson},
  journal={Neurobiology of Disease},
Spinocerebellar ataxia type 1 (SCA1) is a dominantly inherited neurodegenerative disorder caused by polyglutamine repeat expansions in Ataxin-1. Recent evidence supports a role for microRNAs (miRNAs) deregulation in SCA1 pathogenesis. However, the extent to which miRNAs may modulate the onset, progression or severity of SCA1 remains largely unknown. In this study, we used a mouse model of SCA1 to determine if miRNAs are misregulated in pre- and post-symptomatic SCA1 cerebellum. We found a… CONTINUE READING


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