Altered Nucleosome Positioning at the Transcription Start Site and Deficient Transcriptional Initiation in Friedreich Ataxia*

@inproceedings{Chutake2014AlteredNP,
  title={Altered Nucleosome Positioning at the Transcription Start Site and Deficient Transcriptional Initiation in Friedreich Ataxia*},
  author={Yogesh K. Chutake and Whitney N. Costello and Christina C. Lam and Sanjay I. Bidichandani},
  booktitle={The Journal of biological chemistry},
  year={2014}
}
Most individuals with Friedreich ataxia (FRDA) are homozygous for an expanded GAA triplet repeat (GAA-TR) mutation in intron 1 of the FXN gene, which results in deficiency of FXN transcript. Consistent with the expanded GAA-TR sequence as a cause of variegated gene silencing, evidence for heterochromatin has been detected in intron 1 in the immediate vicinity of the expanded GAA-TR mutation in FRDA. Transcriptional deficiency in FRDA is thought to result from deficient elongation through the… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 17 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 33 REFERENCES

The logic of chromatin architecture and remodelling at promoters

  • B. R. Cairns
  • Nature
  • 2009
Highly Influential
16 Excerpts

Similar Papers

Loading similar papers…