Altered Nrf2/Keap1-Bach1 equilibrium in pulmonary emphysema.

@article{Goven2008AlteredNE,
  title={Altered Nrf2/Keap1-Bach1 equilibrium in pulmonary emphysema.},
  author={Delphine Goven and Anne Boutten and V{\'e}ronique Leçon-Malas and Jo{\"e}lle Marchal-Somm{\'e} and Nadia Amara and Bruno Crestani and Michel Fournier and Guy Les{\'e}che and Paul Soler and Jorge Boczkowski and Marcel Bonay},
  journal={Thorax},
  year={2008},
  volume={63 10},
  pages={916-24}
}
BACKGROUND Oxidative stress, resulting from the increased oxidative burden and decreased level of antioxidant proteins, plays a role in the pathophysiology of smoking-related pulmonary emphysema. Expression of several antioxidant proteins, such as heme oxygenase-1 (HO-1), glutathione peroxidase 2 (GPX2) and NAD(P)H:quinone oxidoreductase 1 (NQO1), results from an equilibrium created by positive or negative regulation by the transcription factors Nrf2, Keap1 and Bach1, respectively. However… CONTINUE READING

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