Altered NKp30, NKp46, NKG2D, and DNAM-1 Expression on Circulating NK Cells Is Associated with Tumor Progression in Human Gastric Cancer

@article{Han2018AlteredNN,
  title={Altered NKp30, NKp46, NKG2D, and DNAM-1 Expression on Circulating NK Cells Is Associated with Tumor Progression in Human Gastric Cancer},
  author={B. Han and Fang-yuan Mao and Yong-liang Zhao and Yi-Pin Lv and Yong-sheng Teng and M. Duan and Weisan Chen and P. Cheng and T. Wang and Zhong-yuan Liang and Jin-yu Zhang and Yu-gang Liu and G. Guo and Q. Zou and Y. Zhuang and Liusheng Peng},
  journal={Journal of Immunology Research},
  year={2018},
  volume={2018}
}
Natural killer (NK) cell activity is influenced by a complex integration of signaling pathways activated downstream of both activating and inhibitory surface receptors. The tumor microenvironment can suppress NK cell activity, and there is a great clinical interest in understanding whether modulating tumor-mediated NK cell suppression and/or boosting preexisting NK cell numbers in cancer patients is therapeutically viable. To this light, we characterized the surface receptor phenotypes of… Expand
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